The Role of MCP-1(Monocyte Chemoattractant Protein-1) in Restenosis
نویسندگان
چکیده
Monocyte chemoattractant protein-1 (MCP-1) is a monomeric polypeptide with a low molecular weight that its major activity is associated with monocytes. The polypeptide causes the expression of e-selectin and the infiltration of monocytes into the subendothelial space by inducing a lasting impact on monocytes. MCP-1 activity also activates monocytes and the express of tissue factor (TF), superoxide anions and proinflammatory genes. Other roles identified for MCP-1 is the direct impact of polypeptide on restenosis after surgery. This review article is aimed to use the available resources of database in relation to MCP-1 to discuss in detail about the clinical significances, the signaling pathways in which MCP-1 play a role, gene polymorphism and its effects, the role of MCP-1 in vascular disease, particularly the role in the artery reclogging and finally the gene therapy mediated by MCP-1inhibition on restenosis.
منابع مشابه
Essential role of monocyte chemoattractant protein-1 in development of restenotic changes (neointimal hyperplasia and constrictive remodeling) after balloon angioplasty in hypercholesterolemic rabbits.
BACKGROUND Renarrowing of dilated arterial sites (restenosis) hampers the clinical benefits of coronary angioplasty. Infiltration and activation of monocytes in the arterial wall mediated by monocyte chemoattractant protein-1 (MCP-1) might be a major cause of restenosis after angioplasty. However, there is no direct evidence to support a definite role of MCP-1 in the development of restenosis. ...
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